Deletions of both ABL's SH3 domain and the carboxy-terminal proline-rich SH3-binding sites (ABL-PP), but not single mutations of each, block the ability of BCR–ABL to stimulate spontaneous cell ...

Here we describe seven mutations in the SH3-binding protein SH3BP2 (MIM 602104) on chromosome 4p16.3 that cause cherubism.

SH3, and SH1, respectively], and the DNA- and actin-binding domains are shown.) Tyrosine 177 (Y177) in the BCR portion of the fusion gene and tyrosine 412 (Y412) in the ABL portion are important ...

Article: Jiang X, Saw KM, Eaves A, Eaves C. Instability of BCR-ABL Gene in Primary and Cultured Chronic Myeloid Leukemia Stem Cells. J Natl Cancer Inst 2007; 99: 680-693 RELATED TOPICS ...

Amplification of the BCR-ABL gene leading to overproduction of the TK can confer relative ... KM, Yacobi, R, Van Etten, RA. Autoinhibition of Bcr-Abl through its SH3 domain. Mol Cell 2003;12:27-37.

The genetic changes involving the ABL1 gene in cancer cells consist in the ABL gene fusing with another gene, the BCR gene, in chromosome 22, which is then called the Philadelphia chromosome.

Paris and Strasbourg, France, June 9, 2022 - Coave Therapeutics (‘Coave’), a clinical-stage biotechnology company focused on developing life-changing gene therapies for CNS (Central Nervous System) ...