Chronic myeloid leukemia (CML) cells contain an abnormal gene, BCR-ABL, that isn't found in normal cells. This gene makes a protein, BCR-ABL, which causes CML cells to grow and reproduce out of ...

Based on the results of BCR::ABL fusion gene testing, 33 patients with CML were in molecular ... and detected mutation abundance was performed using the Excel data analysis function. Fisher’s exact ...

The relationships between yeast protein sequences and their biological functions in the context of gene ontology categories are presented, and the effects of the level of gene ontology terms and the ...

Since the rapid dissemination of these testing modalities and others described in this review, discoveries of numerous pathogenic copy number variants (CNVs) and gene mutations have ... early loss of ...

2023). Lian et al., 2021 reports their study on miR-140 directly target PINK1 gene and reduce its expression. PINK1 enhances mitochondrial function and cognition according to the previous studies.

In order to have the potential to acquire a new function, a duplicate gene must come under the protection of natural selection so that it is not eliminated by degenerative mutations. At least ...

Beacon Therapeutics may have found a guiding light in a disease area where other companies have stumbled with its laruparetigene zovaparvovec (laru-zova), a gene therapy that proved early ...

A new gene therapy targeting the heart protein cBIN1 reversed heart failure and restored heart function in pigs, showing unprecedented recovery and a 30% improvement in heart performance. If ...

Cite this: Abl Tyrosine Kinase Inhibitors for Overriding Bcr-Abl/T315I: From the Second to Third Generation - Medscape - Sep 01, 2008.