Actin and its dynamic structural remodelings are involved in multiple cellular functions, including maintaining cell shape and integrity, cytokinesis, motility, navigation, and muscle contraction.

The apoptotic nuclease, DNA fragmentation factor (DFF40/CAD), is primarily responsible for internucleosomal DNA cleavage during the terminal stages of programmed cell death. Previously, we ...

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States Koch Institute for Integrative Cancer Research, Massachusetts Institute of ...

We present here the structure of the catalytic domain responsible for its DNA binding and nuclease activity. Our analysis provides structure-based hypotheses for how XPG recognizes its bubble DNA ...

We thank Audrey R. Odom John, currently the Stanley Plotkin Chair of Pediatric Infectious Diseases and Chief of the Division of Pediatric Infectious Diseases at the Children’s Hospital of Philadelphia ...

Scientists have elucidated the molecular mechanism by which LEM-3 cuts DNA bridges during cytokinesis ... LEM-3 is a nuclease, and nucleases act like a surgical knife on DNA.

and IBS Research Fellow Stephane ROLLAND announced that they have elucidated the molecular mechanism by which LEM-3 cuts DNA bridges during cytokinesis. Cell division is an essential biological ...

If DNA bridges persist between chromosomes during cell division ... bridges and subsequent cell division failure. LEM-3 is a nuclease, and nucleases act like a surgical knife on DNA.

During insight moments, your brain’s visual processing areas work more closely with emotional and memory centers, creating a unified network that strengthens memory formation. This research suggests ...

Misfolding of proteins in the ER result in aggregate formation, but how the aggregates are processed especially during cell division is not well ... cleared as cells progressed through mitosis and ...