Nanomedcine holds great potential in cancer therapy due to its flexibility on drug delivery, protection, releasing, and targeting. Epigenetic drugs, such as 2′-deoxy-5-azacytidine (DAC), are able to ...

The clinically approved drug 5‐azacytidine inhibits nonsense‐mediated decay (NMD) through a MYC‐dependent mechanism. This supports its repurposing to treat Mendelian or acquired genetic diseases that ...

Introduction: Progressing myelodysplastic syndrome (MDS) into acute myeloid leukemia (AML) is an indication for hypomethylating therapy (HMA, 5-Azacytidine (AZA)) and a BCL2 inhibitor (Venetoclax, VEN ...

To summarize, it can be assumed that the biological activity of the novel 2’-fluoro analog 5-azacytidine demonstrates a powerful mechanism for cell cycle arrest and apoptosis induction through ...

Corrigendum: 5-azacytidine promotes microspore embryogenesis initiation by decreasing global DNA methylation, but prevents subsequent embryo development in rapeseed and barley María-Teresa Solís † ...

Researchers presented the case of a patient with whose disease is still in remission after 9 years of azacitidine treatment.