These third-generation aromatase inhibitors include the steroidal drug exemestane, which binds irreversibly to the aromatase enzyme, and the nonsteroidal drugs letrozole and anastrozole, which form ...

Patients received abemaciclib or placebo (150 mg twice daily continuous schedule) plus either 1 mg anastrozole or 2.5 mg letrozole, daily. The primary objective was investigator-assessed ...

This study follows a nested cohort design, including women with a diagnosis of breast cancer starting treatment with tamoxifen, anastrozole, exemestane or letrozole. The risk of RA related to the ...

The combination also showed a manageable safety profile. Another study (SOLTI-1303 PATRICIA) investigated the CDK4/6 inhibitor palbociclib plus trastuzumab with or without letrozole, and findings ...