Background This study aimed to investigate the clinical characteristics, outcomes, and risk factors of patients with a rare but fatal manifestation of systemic lupus erythematosus (SLE), diffusive ...

Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease with varied clinical manifestations and complex pathogenesis. SLE has a significant impact on morbidity, mortality and ...

Background Previous US study presented a claims-based algorithm, consisted with comorbidities and medication information, to classify systemic lupus erythematosus (SLE) severity as mild, moderate or ...

Background Systemic lupus erythematosus is a chronic-systemic autoimmune disease that may affect different organ and organ system. Pathogenesis of SLE is not well understood but high inflammatory ...

Background To compare the prognosis of SLE patients who achieve clinically quiescent following treatment, with or without serologically active. Methods We categorized SLE patients from Lupus Clinic of ...

Objective To describe the pharmacodynamic monitoring of (immuno)proteasome inhibition following treatment with bortezomib in a therapy-refractory systemic lupus erythematosus (SLE) patient with ...

Background/Purpose Diagnosis of Lupus Nephritis (LN) is currently based on laboratory tests and renal histopathology. The role of histopathological features in determining long term outcomes is ...

Objective Sleep deprivation has been associated with risk of autoimmune diseases. We investigated whether it was associated with risk of developing SLE using the Nurses’ Health Study (NHS) (1986-2016) ...

Objective The role of neutrophils in driving pathogenic B cell responses in SLE is not fully understood. In this study, we explored the link between immune complex (IC)–driven neutrophil activation, ...

Objectives Lupus nephritis (LN) is a major cause of morbidity in patients with systemic lupus erythematosus (SLE). B cells have a central role in the pathogenesis of SLE. B lymphocyte stimulator (BLyS ...

Objectives While diffuse alveolar haemorrhage (DAH) is recognised as a life-threatening complication of systemic lupus erythematosus (SLE), little is known about its risk factors and response to ...

Objectives This study aimed to derive and validate a cut-off for severe disease activity (SDA) using the SLE Disease Activity Score (SLE-DAS) and compare its accuracy and impact on health-related ...