Targeting FGFR2 may prevent or delay some KRAS-mutated pancreatic cancers
In a recent study, precancerous pancreatic lesions and some pancreatic ductal adenocarcinoma (PDAC) tumors harboring KRAS ...
News-Medical.Net on MSN3d
FGFR2 identified as key driver in KRAS-mutated pancreatic cancer progression
Precancerous pancreatic lesions and some pancreatic ductal adenocarcinoma (PDAC) tumors harboring KRAS mutations had ...
Pancreatic cells 'remember' cancer-linked epigenetic marks without mutations, study shows
Johns Hopkins Medicine scientists say they have found a pattern of so-called epigenetic "marks" in a transition state between ...
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Inhibiting FGFR2 Supports Prevention and Delay of Common Pancreatic Cancer
Results showed that FGFR2 gene deletion led to significantly fewer precancerous lesions and delayed PDAC tumor formation ...
Science Daily1d
Pancreatic cells 'remember' epigenetic precancerous marks without genetic sequence mutations
Scientists say they have found a pattern of so-called epigenetic 'marks' in a transition state between normal and pancreatic cancer cells in mice, and that the normal cells may keep at least a ...
Science Daily3d
In pancreatic cancer, a race against time
Scientists have found a way to 'intercept' pancreatic cancer. By inhibiting the cancer gene FGFR2, they were able to slow tumor formation. By targeting the FGFR2 and EGFR proteins, they were able to ...
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Targeting FGFR2 may prevent or delay some KRAS-mutated pancreatic cancers
While mutations in the KRAS protein are known to drive pancreatic cancer, these do not appear to be sufficient to promote the transition from precancerous lesions to cancer, Tonelli noted.