The cytoplasmic domain of hSPAR is sufficient to trigger TRIM21/glutamine-P27KIP1-mTOR signaling in MDA-MB-231 cells and suppress xenograft tumor growth. See also Fig. EV5 . ( A ) Changes of ...

mTOR’s pleiotropic functions are catalyzed by two distinct kinase complexes: mTORC1, the key component of which is Raptor, and mTORC2, ... digested with PreScission proteases overnight to release the ...

Egyptian online auto parts marketplace Mtor has raised $2.8 million in pre-seed investment led by Egypt-focused venture capital firm Algebra Ventures. Other investors that participated in the ...

The mammalian target of rapamycin (mTOR) is a protein kinase of the PI3K/Akt signaling pathway that regulates cell growth and division and is an attractive target for cancer therapy. Many reports on ...

Ischemic stroke remains a leading cause of morbidity and disability around the world. The sequelae of serious neurological damage are irreversible due to body’s own limited repair capacity. However, ...

The DEPTOR-mTOR interaction occurs in two steps. In one step, the DEPTOR PDZ domain binds the mTOR FAT domain. The PDZ domain core (aa DEPTOR 326–409) adopts a canonical PDZ fold and binds the TRD2 ...

A small stretch of extra cryo-EM density in mTOR's FRB domain suggested an interaction of DEPTOR with this mTOR domain . As it has been previously reported that DEPTOR’s long-linker is phosphorylated ...

A generic top-level domains is like .com, .net and .org. There’s another kind of domain that’s associated with countries called Country Code top-level Domain (ccTLD). Examples of ccTLDs are ...

CDK4/6 inhibitors or CDK4/6 inhibitor-resistant breast cancer cells activate the PI3K/AKT/mTOR pathway (Herrera-Abreu et al., 2016; Jansen et al., 2017; Pandey et al., 2019). mTOR promotes cell ...