News

The Malaysian Reserve12h
Solve M.E. Selects Simmaron Research As Recipient of ME/CFS Catalyst Award to Accelerate Low-Dose Rapamycin Trial for ME/CFS, Long COVID, and IACCs
The Catalyst Award will expedite the hunt for a validated test-to-treat model for ME/CFS, a disease for which there is ...
Boosting precision gene editing: Autophagy shifts DNA repair toward homologous recombination
Precision gene editing is crucial for treating genetic diseases, as it enables targeted correction of specific mutations. A ...
The New York Times27d
OpenAI Says It Will Build Massive Data Centers in the U.A.E.
As part of a new partnership, G42, an Emirati A.I. firm, will also help fund OpenAI’s new computer facilities in the United States. By Cade Metz and Tripp Mickle Cade Metz and Tripp Mickle have ...
ahajournals.org4mon
New Insights Into the Role of mTOR Signaling in the Cardiovascular System
mTOR interacts with specific adaptor proteins to form 2 multiprotein complexes, called mTORC1 (mTOR complex 1) and mTORC2 (mTOR complex 2). In the cardiovascular system, the mTOR pathway regulates ...
The EMBO Journal4mon
Micropeptide hSPAR regulates glutamine levels and suppresses mammary tumor growth via a TRIM21-P27KIP1-mTOR axis
P27KIP1 accumulation and lysosomal localization disrupt the Ragulator complex to suppress mTOR activation. The cytoplasmic C-terminal domain of hSPAR is sufficient for mTOR inactivation, inhibition of ...
National Geographic news5mon
Can this ‘anti-aging’ drug live up to the hype? Here’s what we know.
Rapamycin (red) inhibits a protein complex called mTORC1 (mammalian target ... Rapamycin works by suppressing a signaling enzyme known as mTOR (short for mechanistic target of rapamycin), which ...
GEN1y
Lifespan in Mice Shortens with Increase in Nutrient Signaling to mTOR
The rapamycin (mTOR) complex 1 (mTORC1) is known to be a key component of multiple functions of the body, including metabolism. Now, a new paper finds that when mTOR activity is slightly increased ...
News Medical1y
Regulation of cytotoxic T-cell differentiation and exhaustion by mTOR signaling
Cytotoxic T lymphocytes play a crucial role in adaptive immunity, primarily defending against tumors and viruses. These cells develop within the thymus gland and undergo rapid activation upon ...
ahajournals.org1y
Loss of Macrophage mTORC2 Drives Atherosclerosis via FoxO1 and IL-1β Signaling
The mTOR (mechanistic target of rapamycin) pathway is a complex signaling cascade that regulates cellular growth, proliferation, metabolism, and survival. Although activation of mTOR signaling has ...
The EMBO Journal3y
The mTORC1‐eIF4F axis controls paused pluripotency
In this study, we demonstrate that mTOR complex 1 (mTORC1) but not complex 2 (mTORC2) mediates mTOR inhibition‐induced paused pluripotency in cells grown in both SL and 2iL medium (GSK3 and MEK ...
eLife3y
Regulation of human mTOR complexes by DEPTOR
Biochemical analysis and cryo-EM reconstructions of DEPTOR bound to human mTOR complex 1 (mTORC1) and mTORC2 reveal that both structured regions of DEPTOR, the PDZ domain and the DEP domain tandem ...