Scientists at Tel Aviv University and the Israel Institute for Biological Research have developed the first mRNA vaccine proven completely effective against deadly bacteria. This groundbreaking ...

The innate immune system is the body's first line of defense against pathogens and foreign substances. An essential component ...

Researchers discovered that a modification to the synthetic mRNA used in therapeutics can cause the cell’s machinery to misread its instructions, leading to unintended immune responses.

The innate immune system is the body's first line of defense against pathogens and foreign substances. An essential component ...

Duke researchers published a breakthrough in understanding m6A through the development of a genetically encoded sensor for the most abundant internal mRNA modification.. These mRNA modifications ...

m6A mRNA modification potentiates Th17 functions to inflame autoimmunity. Science China Press. Journal Science China Life Sciences DOI 10.1007/s11427-022-2323-4. Keywords / Life sciences; ...

He is interested in seeing how the scientists overcome the challenge of mass manufacturing in the future, given that making the branched mRNA requires a prolonged purification process. In the meantime ...

Despite altering the Watson–Crick base pairing, Z-mRNA has favorable properties and could be used to produce alternative mRNA vaccines with fewer side effects. To assess the modified mRNA in vivo, the ...

Cap2 is a variable mRNA modification found in diverse sequence contexts. a, Structure of Cap1-modified and Cap2-modified 5′ mRNA termini. b, RNase T2 (scissors) cleaves RNA only after non-2′-O ...

As of September 2023, more than 13.5 billion COVID-19 vaccine doses — including mRNA vaccines as well as other kinds of shots — had been administered since they first became available in ...

Modifications to the chemical structure of RNA have become a major component of modern health innovation. COVID-19 messenger RNA vaccines, more commonly known as mRNA vaccines, rely on modified RNA.