Summary: New research reveals how a tiny chemical mark on RNA helps wire the brain during development. Scientists discovered ...

More information: Yanqiang Li et al, 2′-O-methylation at internal sites on mRNA promotes mRNA stability, Molecular Cell (2024). DOI: 10.1016/j.molcel.2024.04.011. Provided by Northwestern University ...

Methylation of the mRNA 5′ guanosine cap is essential for efficient gene expression. The 5′ methyl cap binds to eIF4E, which is the first step in the recruitment of mRNA to the 40S ribosomal ...

Researchers at NYU Abu Dhabi discovered how m6A methylation controls the production of essential proteins in neurons, crucial ...

They found that methylation on a particular sequence of an mRNA leads to its degradation and that this control mechanism depends on the worm's diet. These findings are to be read in the journal Cell .

Reducing the methylation of a key messenger RNA can promote migration of macrophages into the brain and ameliorate symptoms of Alzheimer's disease in a mouse model, according to a new study. The ...

The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.

A team of researchers at NYU Abu Dhabi has uncovered a key mechanism that helps shape how our brains are wired, and what can ...

Reducing the methylation of a key messenger RNA can promote migration of macrophages into the brain and ameliorate symptoms of Alzheimer’s disease in a mouse model, according to a new study ...

DNA and RNA methylation, initially thought to operate as distinct pathways, have been shown to interact closely, shifting our understanding of gene regulation. A team of researchers from the ...

Methylation of nitrogen 6 in the adenosine ring, or m 6 A, is the most common chemical change cells make to their own mRNA. The modification can be both physiological and pathological, and bulk ...

Recent work reported in Nature highlighted the importance of methylation on messenger RNA (mRNA). Methyl tags that are added to mRNA can have a dramatic impact on the fate of mRNA transcripts. Now an ...