Compared with viral vectors, non-viral delivery vectors are easier to scale up and have the ability to solve the most critical safety issues. Thanks to the LNP-mRNA vaccine that came to the fore ...

Multi-C2 domain-containing ferlin proteins have key roles in membrane repair and vesicle trafficking, as well as links to ...

"At Sail Biomedicines, we are proud to have contributed to advancing the understanding of lipid nanoparticle surface structures," said Kerry Benenato, Ph.D., Chief Platform Officer at Sail ...

used X-ray crystallography to determine the structure to 10 Å. This suggested that two ApoE proteins bent into horseshoe shapes that partially circled the lipid particles (Peters-Libeu et al., 2006).

Related: Protein-lipid particles to deliver genetic medicine ... Those ionizable lipids, which are remarkably similar in structure, were discovered while the firms were optimizing LNPs for ...

Their structure makes them highly suitable ... Image Credit: InProcess-LSP Lipid-based Nano Particles form a very useful class of delivery systems in the pharmaceutical area as well as in ...

The neutral/structure lipids, such as DSPC and cholesterol provide the general framework or structure of the particles, whereas pegylated lipids coat the surface of the LNPs and provide physical ...

Researchers from the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC) have uncovered the 3D structure of the ...

The difference between these lipids is in how they are structured. The structure of saturated and ... high levels of LDL in your bloodstream, fat particles will attach to the walls of your ...

"It seems that the HDL-like particles containing APOE2 or APOE3 are larger and are more effective at transferring the lipids and cholesterol ... Moreover, "the quality and structure of our fatty ...