HDL particles transport cholesterol and contain apolipoprotein A-I as their major protein. The solution structure of discoidal HDL particles reconstituted with a shortened apoA-I is now solved via ...

the structure of ‘stabilized plasmid-lipid particles’ (splp) and their properties as systemic gene therapy vectors has been investigated. we show that splp can be visualized employing cryo ...

With a new method, researchers have captured a high-resolution metabolic “map” of how cells orchestrate glucose processing, ...

Nanoemulsions, which are fine dispersions of oil and water phases, are particularly effective for incorporating hydrophobic ...

Scientists have struggled to elucidate the structure of lipidated ApoE with biophysical techniques because, even when crystallized or frozen, the proteins shimmy slightly within lipid bilayers.

Lipid nanoparticles (LNP’s) came to prominence for delivery of RNA with the success of the Moderna and Pfizer BioNTech COVID-19 vaccines. They are also used to deliver therapeutic treatments including ...

Tiny fat bubbles carrying gene therapy have successfully repaired DNA in the lungs and liver of animals with alpha-1 ...

The neutral/structure lipids, such as DSPC and cholesterol provide the general framework or structure of the particles, whereas pegylated lipids coat the surface of the LNPs and provide physical ...

New views of enzyme structures offer insights into metabolism of cholesterol, other lipids Date: March 2, 2015 Source: University of Michigan Summary: ...

HANGZHOU, China, January 13, 2025--Studies by HighField Biopharmaceuticals Show Advantages of Lipid Structure Design for Applying LNP Non-Viral Gene Therapies to Complex Diseases ...

Johns Hopkins researchers have identified minuscule particles that supercharge therapeutic cancer vaccines, which train the immune system to attack tumors. These new lipid nanoparticles—tiny ...

The ‘127 patent, granted in August 2016, covers SNALP particles that have a non-lamellar structure and that consist of a nucleic acid (such as one or more interfering RNA), methods of making the ...