The rdHDL particles feature a protein double belt surrounding a lipid bilayer patch in an antiparallel fashion. The integrity of this structure is maintained by up to 28 salt bridges and a zipper ...

Compared with viral vectors, non-viral delivery vectors are easier to scale up and have the ability to solve the most critical safety issues. Thanks to the LNP-mRNA vaccine that came to the fore ...

Multi-C2 domain-containing ferlin proteins have key roles in membrane repair and vesicle trafficking, as well as links to ...

A team led by scientists at the University of Nottingham's School of Pharmacy demonstrated a new cryogenic mass spectrometry approach for depth profiling frozen tiny lipid nanoparticles to reveal the ...

used X-ray crystallography to determine the structure to 10 Å. This suggested that two ApoE proteins bent into horseshoe shapes that partially circled the lipid particles (Peters-Libeu et al., 2006).

Their structure makes them highly suitable ... Image Credit: InProcess-LSP Lipid-based Nano Particles form a very useful class of delivery systems in the pharmaceutical area as well as in ...

The neutral/structure lipids, such as DSPC and cholesterol provide the general framework or structure of the particles, whereas pegylated lipids coat the surface of the LNPs and provide physical ...

Researchers from the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC) have uncovered the 3D structure of the ...

After the lipid-packaged RNA arrives at a cell ... He wonders whether they will modify the cuboplex structure and alter the delivery efficiency. Leal acknowledges that her group hasn’t worked ...

The difference between these lipids is in how they are structured. The structure of saturated and ... high levels of LDL in your bloodstream, fat particles will attach to the walls of your ...

"It seems that the HDL-like particles containing APOE2 or APOE3 are larger and are more effective at transferring the lipids and cholesterol ... Moreover, "the quality and structure of our fatty ...