Unfortunately, cancers inevitably evolve around EGFR inhibition, ... A University of Colorado Cancer Center study published today in the journal Cancer Research details a signaling pathway, ...

Fresh tumor tissue before and after 7 to 14 days of therapy was used for microarray analyses exploring EGFR pathway activity and inhibition. Results. In 102 patients with TNBC, RRs were 6% (two of 31) ...

Background: Determination of the mutational status of key gene effectors along the EGFR signaling pathway plays a critical role in the management of metastatic colorectal cancer (mCRC) and other ...

By administering exogenous ACh, the tenocytes were stimulated to significantly proliferate and increase in viability. In addition, Western blot showed that ACh stimulation resulted in increased ...