Research reveals why EGFR-targeted cancer therapies often face resistance, leading to ongoing studies on combination treatments.

A new review was published in Volume 16 of Oncotarget on June 25, 2025, titled "Challenges and resistance mechanisms to EGFR ...

The Notch signaling pathway is an ancient and highly conserved signaling pathway that controls cell fate specification and tissue patterning in the embryo and in the adult. Region-specific endocardial ...

Visualization of biological mechanisms by means of pathway graphs is necessary to better understand the often complex underlying system. Manual layout of such pathways or maps of knowledge is a ...

A pathway diagram illustrating the DEGs and SCMs in the two soybean lines was generated based on the flavonoid biosynthetic pathway described in model plants. A total of 20 types of flavonoids and 55 ...

The most successful one is lapatinib, which targets EGFR and HER2, a reversible inhibitor that is approved in the treatment of breast cancer with capecitabine. The HKI-272 is an irreversible ...

A Possible Link to the EGFR Pathway Francisca Dias; Ana L Teixeira; Juliana I Santos; Mónica Gomes; Augusto Nogueira; Joana Assis; Rui Medeiros Disclosures Pharmacogenomics. 2013;14 (14):1793-1803.

To further elucidate the relationship between immune-metabolic related DEGs and these pathways, we utilized the Spearman correlation algorithm to assess the correlation between each DEG and the ...