ACROBiosystems has developed a series of specialized proteases for the screening and validation of ADC linkers, focusing on ...

A new review was published in Volume 16 of Oncotarget on June 25, 2025, titled "Challenges and resistance mechanisms to EGFR ...

Research reveals why EGFR-targeted cancer therapies often face resistance, leading to ongoing studies on combination treatments.

The most successful one is lapatinib, which targets EGFR and HER2, a reversible inhibitor that is approved in the treatment of breast cancer with capecitabine. The HKI-272 is an irreversible ...

A Possible Link to the EGFR Pathway Francisca Dias; Ana L Teixeira; Juliana I Santos; Mónica Gomes; Augusto Nogueira; Joana Assis; Rui Medeiros Disclosures Pharmacogenomics. 2013;14 (14):1793-1803.

Borad, M. J. et al. Integrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinoma.

BACKGROUND: Primary aldosteronism (PA), an overt form of renin-independent aldosterone production, leads to a disproportionately high rate of major adverse cardiovascular events (MACEs). Mounting ...

Visualization of biological mechanisms by means of pathway graphs is necessary to better understand the often complex underlying system. Manual layout of such pathways or maps of knowledge is a ...

The Notch signaling pathway is an ancient and highly conserved signaling pathway that controls cell fate specification and tissue patterning in the embryo and in the adult. Region-specific endocardial ...

Activation of the phosphatidylinositol-3-kinase (PI3-K)/protein kinase B (AKT) pathway is associated with three major radioresistance mechanisms: intrinsic radioresistance; tumour-cell proliferation; ...