The Rybrevant-Lazcluze combo significantly reduced the risk of death by 25% versus Tagrisso in patients with newly diagnosed advanced EGFR-mutated NSCLC, according to data from the phase 3 ...

The estimated glomerular filtration rate (eGFR) is a blood test to assess kidney function. The formula for calculating eGFR takes the patient’s body size, age, and sex into account to predict ...

Living kidney donors with discordant kidney function measures had lower eGFR after donation and a higher risk for eGFR counts below 45 mL/min/1.73 m 2, researchers found. “Living donor kidney ...

Here, we report that endosomal-localized EGFR/Ezrin complex interacts with and triggers the ... Loss of Ezrin was not sufficient to repress TSC complex by EGF and culminated in translocation of TSC ...

Please provide your email address to receive an email when new articles are posted on . Newer eGFR calculations that do not consider race show a link between kidney function and dementia.

They found both previously known and novel mutations significantly linked to EGFR activation and drug response, demonstrating the method's precision and revealing new pathways affecting tumor ...

A schematic diagram showing the significant contribution of SCoV2-induced altered mitochondrial dynamics and mitochondrial EGFR translocation in sustaining viral propagation. First, SCOV2 RNA and ...

Pinetree Therapeutics will help AstraZeneca plant some trees in its pipeline with a new pact to develop a preclinical EGFR degrader worth $45 million upfront for the small biotech. AstraZeneca is ...

Osimertinib is the leading treatment for patients with EGFR-mutant NSCLC, but resistance mutations, including L858R/C797S and L858R/T790M/C797S, have emerged in the clinic.

Thus, advanced understanding of endosomal EGFR signaling and how it may impact tumor viability are necessary before this strategy is viable for combination therapy with TKIs. Finally, nuclear ...

As the number of lung cancer cases drops overall due to declining smoking rates, the need for treatments for those with EGFR-mutant driven lung cancer rises in importance. This was reflected by 3 ...