Here, we report that endosomal-localized EGFR/Ezrin complex interacts with and triggers the ... Loss of Ezrin was not sufficient to repress TSC complex by EGF and culminated in translocation of TSC ...

Further pieces of evidence prove that, as well as GP73/EGFR interaction, MMP-2 and MMP-7 interact with the cytoplasmic domain of GP73, and GP73 is involved in their translocation from cytosol to ...

It shows how adjusting eGFR results for body surface may improve decision results. The National Kidney Foundation published a consensus document that advocates transition to race-free eGFR ...

Hear Daniel, husband of a lung cancer survivor, discuss the importance of comprehensive biomarker testing. EGFR-positive lung cancer patient, Ashley, shares what she would tell a newly diagnosed ...

During a Case-Based Roundtable® event, Joshua K. Sabari, MD, continued discussion of key outcomes from the MARIPOSA trial and toxicity management in patients with EGFR-mutated non–small cell lung ...

The latest semaglutide (Ozempic; Novo Nordisk) approval is set to tackle a major need for patients with both type 2 diabetes (T2D) and chronic kidney disease (CKD), addressing their cardiovascular ...

It is likely that in the near future, more comprehensive PGx studies that involved epigenetic factors, such as miRNA, DNA methylation and histone modification, will be the new norm for PGx ...

There is conflicting evidence about whether CKD, specifically low estimated glomerular filtration rate (eGFR), is a risk factor for stroke independent of traditional cardiovascular risk factors. In a ...

Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) have been extensively studied. Their pleotropic roles were observed in multiple steps of tumor progression and metastasis, ...