Increased activity in a specific biological pathway may explain why many patients with a deadly form of skin cancer do not respond to the latest ...

In a recent study, researchers have uncovered the biological trigger behind the dangerous immune-related adverse events (irAEs) that occur when the ...

Le et al: These data aligned with previous randomized clinical trials combining VEGF pathway inhibitors with first-generation EGFR TKIs. In the [2019] RELAY study, the addition of ramucirumab to ...

However, this relies upon the assumption that drug-tolerant cells isolated in monolayer culture are at least reasonably similar in nature to drug-tolerant ... from 5 cell lines representing the ...

Detailed studies on nongenomic signaling pathways, particularly the interaction between AhR and EGFR, could provide new insights into ... partially attributed to PM2.5. LoPiccolo et al (2024). Nature ...

Mechanistically, disruption of EGFR signaling generated a cell-intrinsic hypersensitivity within the JAK-STAT1 pathway, which, synergistically with interferon gamma expressing CD8 T-cell and ...

Copyright: © 2023 Elsevier Ltd. All rights reserved. Epidermal growth factor receptor (EGFR) and its activated downstream signalling pathways play a crucial role in ...

One pathway that is affected by cancer is the epidermal growth factor receptor (EGFR) pathway. As this signaling chain is usually overactivated in cancer, treatment options often include EGFR ...

The organoid with the mutation is greener than the one without the mutation, meaning that it has higher activity of the EGFR signaling pathway. The Organoid group at the Hubrecht Institute have ...

By activating the EGF/EGFR signaling pathway and downstream cascades, such as Src/PI3K/Akt/mTOR, it may be possible to enhance the motility and proliferative capacity of oral keratinocytes during ...