Nakagawa et al: The stratified OS HR was 0.98 (95% CI 0.78-1.24, P=0.864), median OS (mOS) was 51.1 months for RAM-ERL and 46.0 months for placebo-ERL.For the subgroups of patients by EGFR ...

Conclusions: This study showed that positive EGFR exon20ins in plasma ctDNA is associated with advanced disease characteristics. Sunvozertinib can effectively clear EGFR exon20ins in plasma ctDNA, ...

New link with the EGFR signaling pathway. Mutations leading to colon cancer affect a wide range of signaling pathways; these consist of chains of molecules that send messages to each other in ...

New link with the EGFR signaling pathway. Mutations leading to colon cancer affect a wide range of signaling pathways, these consist of chains of molecules, which send messages to each other in ...

The Organoid group at the Hubrecht Institute have identified a new link between FBXW7 mutations and EGFR signaling activity. The FBXW7 gene is commonly mutated in colorectal cancer and such ...

The article, “The EGF/EGFR axis and its downstream signaling pathways regulate the motility and proliferation of cultured oral keratinocytes” was published on 27 May 2023 in FEBS Open Bio ...

Sunvozertinib (DZD9008), a selective and irreversible EGFR exon20 insertion inhibitor with EGFR wild-type selectivity, showed significant anti-tumor efficacy and was well-tolerated in patients with ...

e21019Background: The purpose of our study is to explore patterns in gene expression for patients with EGFR-mutated non-small cell lung cancer (NSCLC). ... RNA sequencing to characterize pathways in ...

Beveridge, now with Avalere Health, addressed the importance of clinical pathways in selecting therapies in non-small cell lung cancer (NSCLC) and the emergence of options for EGFR Exon 20 ...

Edward Arrowsmith, MD, MPH, medical director for clinical pathways for OneOncology, discussed treatment challenges in EGFR Exon 20 insertion+ non-small cell lung cancer (NSCLC) and best practices ...

In this study, we demonstrated, for the first time, that activation of the epidermal growth factor receptor (EGFR)-mediated signaling pathway is involved in lenvatinib resistance in thyroid cancer ...