In a recent study, researchers have uncovered the biological trigger behind the dangerous immune-related adverse events ...

Pathway-focused metabolite ratio-based analysis of 49 tumor and 8 normal epithelial cell lines grown in their respective ...

The epidermal growth factor receptor (EGFR) pathways have been investigated as a potential target for cancer therapy because EGFR overexpression is frequently observed and associated with a poor ...

Le et al: These data aligned with previous randomized clinical trials combining VEGF pathway inhibitors with first-generation EGFR TKIs. In the [2019] RELAY study, the addition of ramucirumab to ...

The long pathway to cell organization and growth Date: May 15, 2025 Source: University of California - San Diego Summary: Sterols are among the most abundant lipids in eukaryotic cells, yet are ...

PET scan as a prognostic marker in advanced colorectal cancer. This is an ASCO Meeting Abstract from the 2014 Gastrointestinal Cancers Symposium. This abstract does not include a full text component.

Clinical activity and biomarkers of MEDI4736, an anti-PD-L1 antibody, in patients with NSCLC. This is an ASCO Meeting Abstract from the 2014 ASCO Annual Meeting I. This abstract does not include a ...

The HER3-directed ADC will be tested in patients whose disease had progressed despite earlier treatment with EGFR inhibitors, including third-generation drugs like AZ's Tagrisso (osimertinib).

There are still many unanswered questions on the use of EGFR treatment in NSCLC Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, is frequently overexpressed in non-small cell lung ...

This study reveals that autophagy affects the occurrence and development of lung cancer through multiple pathways. Then ... transmembrane glycoprotein mucin 1; NOX4, NADPH oxidase 4; Nrf2, nuclear ...

Purpose: To investigate the correlation between single-nucleotide polymorphisms (SNPs) of the Epidermal growth factor receptor (EGFR) gene and its protein expression with susceptibility and survival ...