In summary, CS2011 has demonstrated potent blockage activity on EGFR and HER3 and exhibited synergistic effects on their downstream signaling. It thereby shows the potent tumor growth inhibitory ...

A new review was published in Volume 16 of Oncotarget on June 25, 2025, titled "Challenges and resistance mechanisms to EGFR ...

The link between EGFR signaling and FBXW7 mutations is important to investigate in order to improve treatment options for colorectal cancer. Currently, many patients are treated with EGFR ...

“With topical BRAF inhibition, there is a paradoxical upregulation of the downstream MAP kinase pathway,” she said. “This reverses the effects of the EGFR inhibition in the skin only.

Constitutively active signaling downstream of KRAS is a fundamental driver of lung tumorigenesis. KRAS is the most commonly mutated oncogene in lung adenocarcinomas, ranging in incidence from 15 ...

SUZHOU, China, May 6, 2025 /PRNewswire/ -- CStone Pharmaceuticals ("CStone", HKEX: 2616), an innovation-driven biopharmaceutical company focused on anti-cancer therapies, announced today that ...

EGFR and HER3 are members of the human epidermal growth factor receptor (HER) family and are validated therapeutic targets in advanced solid tumors. EGFR overexpression drives tumor progression in ...