Changes in ctDNA can predict long-term outcomes in certain patients with metastatic CRC on immune checkpoint inhibitors.

Using ctDNA test results to guide adjuvant treatment with pembrolizumab can provide benefits in patients with dMMR solid tumors, data suggest.

The global metastatic colorectal cancer (mCRC) market is expanding rapidly, fueled by rising colorectal cancer cases, therapy advancements, and a focus on patient outcomes. mCRC, a severe cancer form, ...

MOMA Therapeutics, a clinical-stage biopharmaceutical company discovering and developing a new generation of precision therapeutics, today announced that the first patient has been dosed in its Phase ...

Several ASX-listed biotechs are advancing cell therapies to capture a share of a global market projected to reach US$48 ...

Invikafusp alfa, a dual T-cell agonist targeting subsets of tumor-infiltrating lymphocytes, can elicit responses in patients with heavily pretreated gastrointestinal cancers, according to research ...

GSK’s Jemperli has been cleared for routine use by the NHS as a first-line treatment for hundreds of women with dMMR/MSI-H endometrial cancer.

The Lynparza/Imfinzi regimen reduced that endpoint for patients with pMMR disease by 43% compared to the control arm, while Imfinzi cut it by 57% for the dMMR subjects.

In this Review, the authors discuss the epidemiology, biology, pathogenesis, clinical diagnosis and treatment of MSI-H/dMMR tumours, highlighting idiosyncrasies associated with specific ...

Tumours with deficient DNA mismatch repair (dMMR) leading to a microsatellite instability-high (MSI-H) phenotype are characterized by a high burden of immunogenic mutations and, thus, an ...

ATOMIC is the first phase 3 trial to demonstrate the benefit of adding immunotherapy in the adjuvant setting for colon cancer. The results support the integration of atezolizumab into first-line ...

Molecular testing of colorectal cancers (CRCs) to improve patient care and outcomes of targeted and conventional therapies has been the center of many recent studies, including clinical trials.