This useful manuscript describes cryo-EM structures of archaeal proteasomes that reveal insights into how occupancy of binding pockets on the 20S protease regulates proteasome gating. The evidence ...

A new method uses magnetic beads to hold molecules in place, keeping the sample intact and reducing sample loss by a ...

This process tethered the target molecules to the magnetic beads, and the magnetic beads to the grid. With the particles securely in place, blotting could then be done safely, with far less sample ...

and the magnetic beads to the grid. With the particles securely in place, blotting could then be done safely, with far less sample loss. "In traditional cryo-EM, the target molecules just float ...

If you’ve been waking up and feel like your face is looking puffy, learning how to use cryo-facial tools at home could be a game-changing step in your morning skin care routine. After only a few ...

When a power plant trips offline or demand suddenly spikes, the power grid has no cushion; it must respond instantly or it unravels. That's where inertia comes in. In coal, gas, and nuclear plants ...

Thick multicellular plant samples provide unique challenges when it comes to cryo-preservation, which has resulted in limited successful examples for structural studies using in situ cryo-electron ...

Researchers explore how merging X-ray imaging and cryo-EM could enable real-time, high-resolution views of biology, advancing molecular films and drug design. By combining ideas and approaches ...