PP2A can also enhance Wnt signaling by dephosphorylating β-catenin, APC, and Axin. The result is the preservation of β-catenin by preventing ubiquitination and proteasomal breakdown.

A new research paper was published in Volume 16 of Oncotarget on July 21, 2025, titled “Statins exhibit anti-tumor potential ...

Jacob E. Berchuck, MD, highlights novel findings pointing to androgen receptor signaling and Wnt pathway activation as key ...

Wnt/β-catenin signalling might also cause podocyte dysfunction by inducing expression of the canonical transient receptor potential cation channel 6 (TRPC6), a calcium channel that is expressed ...

Wnt signaling appears to be involved in multiple aspects of tumorigenesis. Extensive studies have focused on the regulation of β-catenin levels by the destruction complex, ...

Ciprofol, an innovative anesthetic derived from propofol, has not yet been studied in detail regarding its effects in colorectal cancer (CRC). This study mainly explored the effects of Ciprofol on the ...

Researchers at the University of Illinois, Urbana-Champaign, developed an approach using blue light to activate the Wnt signaling pathway in frog embryos. The pathway plays a wide variety of roles ...

Wnt signalling interpreted differently depending on the receiving cell and signal duration. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2023 / 07 / 230719112618.htm ...

Researchers have captured images of an enzyme for Wnt lipidation, which is pivotal to human development and cancer and crucial for Wnt signaling activation. The findings shed light on the ...

All told, the data paint noncanonical Wnt signaling as promoting Aβ production. The results hint at an Aβ feedback loop. Since the peptide promotes Dkk1 expression, and Dkk1 ultimately raises Aβ, then ...

In agreement with these observations in animal models, they found that Wnt signaling is increased in NEDAMSS patients, whose cells are known to have reduced levels of IRF2BPL. To understand how ...