β-Catenin can then displace the inhibitory TLE/Groucho complexes, enabling TCF/LEF to transcribe the target genes. PP2A can also enhance Wnt signaling by dephosphorylating β-catenin, APC ...

While LGK974 was effective in reducing the vascular expression of the Wnt/β-catenin/TCF signaling target gene Axin2, it did not significantly curtail the progressive enlargement of the aortic ...

A study published today in Journal of Biology reveals that Dishevelled, a key player in the Wnt/beta-catenin signalling pathway, has to be localised in the nucleus to perform a key aspect of its ...

The non-canonical pathway or β-catenin-independent pathway is further divided into the Planar Cell Polarity pathway and the Wnt/Ca2+ pathway. Wnt signalling via Frizzled receptors directs ...

An imbalance of Wnt signaling in Dupuytren's disease could cause fibroblasts in the fascia of the hand to proliferate and form nodules. Indeed, increased levels of β-catenin have been observed in ...

USP7 protects β-catenin in cells, leading to its accumulation when the APC gene is mutated. USP7 inhibition/depletion inhibits Wnt signaling in APC mutant colorectal cancers by restoring β-catenin ...

The research, which appeared in the journal Development, examined a process called Wnt/beta-catenin signaling in mice during heart valve development. The UO team showed how the process ...

marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt/β-catenin signaling, Proceedings of the National Academy of Sciences (2016). DOI: 10.1073/pnas.1601599113 ...

“The Wnt/β-catenin signaling pathway is one of the most frequently activated oncogenic pathways and a well-described driver of many cancers, but this target had been frustratingly beyond ...

A study published today in Journal of Biology reveals that Dishevelled, a key player in the Wnt/beta-catenin signalling pathway, has to be localised in the nucleus to perform a key aspect of its ...