Photodynamic therapy (PDT) resistance limits treatment efficacy in oral leukoplakia (OLK). This study identifies p-NRF2 as a ...

Figure 3: Inhibition of the Wnt/b-catenin pathway induces defects in CNS formation. Taken together, our results suggest that the Wnt/β-catenin pathway, whose function involves an axin-based ...

The canonical Wnt signaling pathway. The left panel (A ... In the absence of Wnt signaling (B), the destruction complex breaks down β-catenin and inhibits gene transcription.

It arises from chronic liver diseases, including hepatitis B or C infections ... the crucial role of the Wnt signaling pathway, especially its β-catenin axis, in HCC. This pathway regulates ...

These are classified as the canonical, or Wnt/β-catenin pathway, and the non-canonical, or β-catenin-independent, pathway. The non-canonical pathway is further divided into the Planar Cell ...

A Wnt/β-catenin pathway agonist under development by Surrozen appears to be effective against idiopathic pulmonary fibrosis (IPF) in mouse models, according to new data. The results, published ...

For the very first time, we are uniting leading pharma, pioneering biotechs and reputed academics at the Wnt & β-Catenin Targeted Drug Discovery Summit this November to share lessons learned to ...

In conclusion, the study underscores the significant role of the Wnt/β-catenin pathway in human and experimental AAA, but the therapeutic interventions tested, LGK974 and PRI-724, showed limited ...

Panel B shows that if Wnt signaling is active, β-catenin degradation is reduced. SFRPs antagonize the Wnt-signaling pathway by binding to either Wnt or frizzled receptor, thereby affecting ...

The researchers started their quest by looking at WNT signaling, a communication pathway used by cells to promote tissue regeneration and wound healing. WNT signaling helps maintain the blood ...