It arises from chronic liver diseases, including hepatitis B or C infections ... the crucial role of the Wnt signaling pathway, especially its β-catenin axis, in HCC. This pathway regulates ...

There is, however, controversy in the field of osteosarcoma as to whether WNT signaling is pro- or anti-tumorigenic. WNT5B, a β-catenin-independent ... or non-canonical pathways are activated ...

A Wnt/β-catenin pathway agonist under development by Surrozen appears to be effective against idiopathic pulmonary fibrosis (IPF) in mouse models, according to new data. The results, published ...

The canonical Wnt signaling pathway. The left panel (A ... In the absence of Wnt signaling (B), the destruction complex breaks down β-catenin and inhibits gene transcription.

Y. et al., 2022). The antimalarial compounds artemisinin, dihydroartemisinin, and artesunate halt lung tumor progression by blocking the Wnt/β-catenin pathway. They suppressed Wnt5-a/b protein levels ...

Key proteins in the Wnt/β-catenin pathway including active β-catenin, Bcl-2, and Cyclin D1 were assessed. CTNNBIP1 was upregulated while miR-486-3p was downregulated in osteoporosis patients and OVX ...

The horizontal lines represent mean of replicates. B. Stabilized β‐catenin prevents the downregulation of HR and FA pathway genes upon Wnt inhibition. Mice bearing HPAF‐II xenografts without or with ...

The Wnt pathway communicates signals from the outer cell membrane all the way into the cell nucleus with messages being carried from membrane-bound proteins to cytosolic proteins to intranuclear ...

Specifically, we addressed the questions, a) if the Wnt/β-catenin pathway is operational in ECs of CVOs during murine development and in the adult mouse and zebrafish, b) if endothelial-specific, ...