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Study reveals new indicators for HER2+ breast cancer response to therapy
Envision this possible future clinical scenario: a breast cancer patient and her physicians are deciding on the best possible ...
Frontiers13d
Differential Metabolic Pathways Underlie THC-and CBD-Mediated Inhibition of B-Cell Activation in Both Young and Aged Mice
Objective: B lymphocytes play a crucial role in immunity but also contribute ... Although some metabolites, such as glucose-6-phosphate, pentose phosphate pathway (PPP) and nucleotide metabolites, ...
rmdopen.bmj17d
Variants of genes implicated in type 1 interferon pathway and B-cell activation modulate the EULAR response to rituximab at 24 weeks in rheumatoid arthritis
Background The type 1 interferon (IFN) pathway has been identified to potentially affect ... Only corticosteroids and non-steroidal anti-inflammatory drugs were permitted if at stable doses. B-cell ...
Frontiers20d
Activation of the Wnt signaling pathway and its role in epithelial-mesenchymal transition and hepatic fibrosis in alveolar echinococcosis
3.3 Elevated Wnt3a and β-catenin expression in liver tissue of patients with AE The Wnt/β-catenin signaling pathway plays a key role in hepatic fibrosis. Elevated protein expression levels of Wnt3a ...
SciELO21d
Naringin attenuates acute myocardial ischemia-reperfusion injury via miR- 126/GSK-3β/β-catenin signaling pathway
The GSK-3β/β-catenin signaling pathway was examined by Western blotting ... As it is shown in Fig. 4 a-b, OGD/R treatment increased the phosphorylation of GSK-3β and more β-catenin in AC16 cells. Yet, ...