John Mahoney's Martin Crane was the polar opposite of Frasier and Niles, which is exactly what the hit NBC series needed.

Frasier is one of the most successful sitcom spin-offs in TV history, and with it came plenty of guest stars who you might have forgotten were ever on the show.

David Hyde Pierce, who played Frasier's brother, Niles Crane, on the original, and Jane Leeves, who played Niles' love interest Daphne Moon, are not part of the reboot. Grammer, a father of seven ...

I don’t know where Jane Leeves [who played Martin’s caretaker, Daphne] was from. Peri [Gilpin, who played Frasier’s radio producer Roz] had been on “Cheers,” so I knew she could do it.

Also in the mix is Frasier’s nephew (and Niles and Daphne’s son) David, played by Anders Keith, and Freddy’s friend Eve (Jess Salgueiro). Returning to “Frasier” wasn’t part of Grammer ...

For nearly 40 years, Grammer has played, rather to perfection, the ever erudite Frasier Crane ... so do you have any ideas about what Niles and Daphne and Roz and all these characters are up ...

David Hyde Pierce, who played Frasier’s brother, Niles, in the original series, turned down a role in the reboot. Enter David, son of Niles and Daphne, an anxious, flighty freshman at Harvard ...

Kelsey Grammer played Dr. Frasier Crane on "Cheers ... recurring role on "Murphy Brown" before starring as Daphne Moon on "Frasier" in 263 episodes from 1993 to 2004. The role earned her Emmy ...

To be honest, even Grammer feels off the mark, as though he’s doing an impression of this character he played for ... s live-in caregiver Daphne sort of just freaked Frasier out at the start ...

Lilith’s ice-queen status is played up and new gags are ... realises the magnitude of their decisions: Frasier declaring “I am wounded!”, Daphne, fed up with Niles and Frasier storming ...