This valuable study investigates how stochastic and deterministic factors are integrated during cellular decision-making, particularly in situations where cells differentiate into distinct fates ...

Targeting can be achieved by homologous recombination in some organisms (notably, mice), or with site-directed genome editing nucleases. Focal gene amplification is a common feature of advanced ...

They are particularly deleterious as the DNA ends can promote potentially lethal chromosomal rearrangements, and can be repaired by homologous recombination (HR) or non-homologous-end joining (NHEJ).

gretroviral and lentiviral vectors with a vector-specific nonrandom integration pattern in target cell genomes as revealed by integration analysis. Further optimization is needed for reduction of ...

The ASEAN-5 region, which comprises Indonesia, Malaysia, the Philippines, Singapore, and Thailand, has benefited substantially from its integration to the world economy, particularly through trade.