Samples corresponding to colorectal cancer cases were obtained from the Ontario Tumor Bank (Ontario Institute for Cancer Research, ON, Canada), BC Cancer Agency (Vancouver, BC, Canada) and St Paul ...

describe a novel metabolic ‘safety switch’ based on the disruption of uridine monophosphate synthetase (UMPS) — an enzyme that catalyses the biosynthesis of the nucleotide UMP — and ...

In the long term, uridine could be a potential target for therapeutics against eating disorders in humans. Uridine is known primarily as a precursor for RNA, but also plays a central role in many ...

Orally-administered uridine triacetate (vistonuridine) prevents or diminishes toxicities when administered after 5FU overexposure, and has been used successfully as an antidote in more than 28 ...

Uridine triacetate (vistonuridine) is an orally bioavailable prodrug of uridine, a direct biochemical antagonist of 5-FU toxicity. Uridine nucleotides derived from uridine triacetate dilute ...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses a uridine-specific endoribonuclease, called nonstructural protein 15 (Nsp15), to evade the immune system. It works by cleaving ...