Cannabis cream relieved itching symptoms over the short-term in a small trial of patients on hemodialysis experiencing uremic pruritus.

Except for gabapentin, evidence for 38 other treatments is weak and limited by small studies with a high risk of bias, new review finds. Gabapentin is the only treatment for uremic pruritus in ...

Aside from kidney transplantation, no effective treatment exists for uremic pruritus. The capacity of κ-opioid stimulation to block µ-opioid-induced itching implies that the new κ-opioid ...

A kappa opioid receptor agonist is safe and effective for the treatment of pruritus associated with chronic kidney disease, researchers report.

Using PAD Technology and based on a new understanding of the physiopathology of uremic pruritus, Mc2 therapeutics is developing a non-steroidal PAD cream-based drug candidate designed to relieve ...

Uremic Pruritus: Chronic itching associated with the build-up of urea and other toxins in the body, typically observed in patients with advanced kidney disease.

The two most advanced programs are focused on new chemical entity antagonists targeting MrgprX4 and MrgprX2 for the treatment of cholestatic/uremic pruritus, and a broad range of mast-cell ...

Cholestatic Pruritus clinical trials are ongoing with novel agents that demonstrate potential efficacious options in the future. The key players such as Escient Pharmaceuticals, Cara Therapeutics ...

Korsuva, Cara's FDA-approved injection for pruritus, faces challenges in capturing market share for uremic pruritus treatment due to competition, high costs, and modest efficacy.

Trevi Therapeutics announced statistically significant results from its Phase 2/3 trial of Nalbuphine ER for the treatment of moderate to severe uremic pruritus.

A topical cream containing cannabis “significantly reduced the severity of itching” symptoms in patients with chronic kidney disease-related pruritus, according to published data.Many ...

In another study, patients with uremic pruritus on maintenance hemodialysis were treated for 3 weeks with a topical cream that included endogenous cannabinoids.