eLife2d
Elucidating the Mechanism Underlying UBA7•UBE2L6 Disulfide Complex Formation
UBA7 displays a unique capacity to recognize UBE2L6, distinct from this latter’s homolog UBE2L3, highlighting the intricacies of cellular regulation. Inter-species interactions of the resulting ...
eLife2d
Elucidating the Mechanism Underlying UBA7•UBE2L6 Disulfide Complex Formation
(2) The authors carried out a comparative analysis of E1-E2 disulfide bond formation with UBA1, the major activating enzyme for ubiquitin, and UBE2L3, a ubiquitin-specific E2. The choice of UBE2L3 was ...
Frontiers24d
Ubiquitin-proteasome system: a potential participant and therapeutic target in antiphospholipid syndrome
APS (antiphospholipid syndrome) is an autoimmune disease characterized by thrombosis, pregnancy complications and persistent elevation of aPLs (antiphospholipid antibodies). Dysfunction of innate ...
BMJ29d
Immune cell multiomics analysis reveals contribution of oxidative phosphorylation to B-cell functions and organ damage of lupus
Correspondence to Dr Keishi Fujio, Department of Allergy and Rheumatology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan; fujiok-int{at}h.u-tokyo.ac.jp; Dr Yukiko Iwasaki, Department of Palliative ...