News

The University of Alabama at Birmingham1h
Reelin marks cocaine-activated brain neurons and regulates cocaine reward
In a study published in Science Advances, University of Alabama at Birmingham researchers led by Kasey Brida and Jeremy Day, ...
C&EN4d
All-Atom Simulations Reveal the Intricacies of Signal Transduction upon Binding of the HLA-E Ligand to the Transmembrane Inhibitory CD94/NKG2A Receptor
The simulated models revealed that an intricate interplay of events is taking place between the EC and TM regions ultimately affecting the intracellular immunoreceptor tyrosine-based ... signaling ...
Nature5d
Targeting protein kinases in central nervous system disorders
With several hundred kinases encoded in the human genome, almost every signal transduction process is influenced by interconnected phosphorylation events. Deregulation of kinase activity has been ...
gut.bmj22d
Inhibition of spleen tyrosine kinase as treatment of postoperative ileus
Recently it has been shown that spleen tyrosine kinase (Syk) is involved in mast cell degranulation. Therefore, we have evaluated the effect of the Syk-inhibitor GSK compound 143 (GSK143) as potential ...
IEEE25d
Knowledge Representation of G-Protein-Coupled Receptor Signal Transduction Pathways
Better understanding of GPCRs and the signal transduction pathways can help biologists to target new drugs or regulate many important cellular functions for diseases. In this paper, we introduce ...
Frontiers25d
The role of microglia in multiple sclerosis: implications for treatment with Bruton’s tyrosine kinase inhibitors
Additionally, ongoing clinical trials of Bruton’s tyrosine kinase (BTK) inhibitors were identified through the ClinicalTrials.gov website in November 2023 and updated in March 2025. Results: Microglia ...
C&EN26d
Discovery of Imidazo[1,2-b]pyridazine Derivatives as Potent and Highly Selective Irreversible Bruton’s Tyrosine Kinase (BTK) Inhibitors
Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Engineering Research ...
The EMBO Journal28d
Bacterial effectors mediate kinase reprogramming through mimicry of conserved eukaryotic motifs
whereby the canonical serine/threonine host kinase GSK3 gains tyrosine-directed activity towards neosubstrates, promoting Salmonella virulence. Yet, both the mechanism behind the switch in GSK3’s ...