In a study published in Science Advances, University of Alabama at Birmingham researchers led by Kasey Brida and Jeremy Day, ...

The simulated models revealed that an intricate interplay of events is taking place between the EC and TM regions ultimately affecting the intracellular immunoreceptor tyrosine-based ... signaling ...

With several hundred kinases encoded in the human genome, almost every signal transduction process is influenced by interconnected phosphorylation events. Deregulation of kinase activity has been ...