Src tyrosine kinase plays key roles in signal transduction following growth factor stimulation and integrin-mediated cell-substrate adhesion. Since src-signal transduction defects are implicated ...

Han, R.J. Ulevitch, R.J. Davis, "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine ... Medical ...

MEK1/2 is another kinase involved in signal transduction, resulting in the ... Building on the success of targeting protein tyrosine kinases in oncology, RCTs of inhibitors to the tyrosine kinases ...

“This is a major discovery in the field of signal transduction,” Chin said. “Tyrosine phosphorylation has so far been considered the major player in signal transduction. But what we ...

This signal transduction system comprising growth factors ... Ligand binding induces activation of the intracellular tyrosine kinase domain leading to the initiation of signaling events specific for ...

In tomorrow's Science Express, researchers report a link between ErbB-4 signal transduction and γ-secretase, a protease best known for its role in amyloid precursor protein (AβPP) and Notch processing ...

Since tyrosine kinase activity is essential to the transforming ... tyrosine phosphorylation of proteins involved in BCR-ABL signal transduction. It shows a high degree of specificity for BCR ...

Compared to other chemotherapeutics tyrosine kinase inhibitors are generally ... of EFGR by preventing ATP from binding, inhibiting signal transduction. The response rate of this drug is ...

Almost all cancer cells show high expression of signaling components including growth factor receptor tyrosine kinases ... Advances in Cancer Signal Transduction and Therapy covers advancements ...

Gefitinib is supplied in 250 mg tablets; the recommended daily dose being 250 mg once daily, with or without food. The elimination half-life is 48 hours and the mean bioavailability is 60%.

Cohen, D.T. Dudley, A.R. Saltiel, "PD098059 is a specific inhibitor of mitogen-activated protein kinase kinase in vitro and in vivo ... Saltiel, department of signal transduction, Parke-Davis, Ann ...