Src tyrosine kinase plays key roles in signal transduction following growth factor stimulation and integrin-mediated cell-substrate adhesion. Since src-signal transduction defects are implicated ...

Han, R.J. Ulevitch, R.J. Davis, "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine ... Medical ...

“This is a major discovery in the field of signal transduction,” Chin said. “Tyrosine phosphorylation has so far been considered the major player in signal transduction. But what we ...

Almost all cancer cells show high expression of signaling components including growth factor receptor tyrosine kinases ... Advances in Cancer Signal Transduction and Therapy covers advancements ...

Since tyrosine kinase activity is essential to the transforming ... tyrosine phosphorylation of proteins involved in BCR-ABL signal transduction. It shows a high degree of specificity for BCR ...

In tomorrow's Science Express, researchers report a link between ErbB-4 signal transduction and γ-secretase, a protease best known for its role in amyloid precursor protein (AβPP) and Notch processing ...

MEK1/2 is another kinase involved in signal transduction, resulting in the ... Building on the success of targeting protein tyrosine kinases in oncology, RCTs of inhibitors to the tyrosine kinases ...

Gefitinib is supplied in 250 mg tablets; the recommended daily dose being 250 mg once daily, with or without food. The elimination half-life is 48 hours and the mean bioavailability is 60%.

Compared to other chemotherapeutics tyrosine kinase inhibitors are generally ... of EFGR by preventing ATP from binding, inhibiting signal transduction. The response rate of this drug is ...

Cohen, D.T. Dudley, A.R. Saltiel, "PD098059 is a specific inhibitor of mitogen-activated protein kinase kinase in vitro and in vivo ... Saltiel, department of signal transduction, Parke-Davis, Ann ...