Patients with type 2 diabetes mellitus are at a higher risk of developing heart failure compared with the healthy population. In recent landmark clinical trials, sodium-glucose co-transporter 2 (SGLT2 ...

The mechanism of action (MoA) of a clickable fatty acid analogue 8-(2-cyclobuten-1-yl)octanoic acid (DA-CB) has been investigated for the first time. Proteomics, metabolomics, and lipidomics were ...

In an attempt to discover natural-product-derived novel green herbicides, 26 novel 3-carene-based acylhydrazone compounds were designed and synthesized. Their chemical structures were characterized by ...

Background: Neoadjuvant taxane, carboplatin and trastuzumab plus pertuzumab is associated with excellent treatment outcomes. The neoCARHP study aimed to evaluate the efficacy and safety of a ...

By inhibiting PARP and blocking WNT pathway activation, stenoparib’s unique therapeutic action shows potential as a promising therapeutic for many cancer types, including ovarian cancer. Allarity has ...

The prevention of unplanned pregnancies is a global problem that requires immediate attention. The livelihoods of both men and women are affected by this issue. The best way to prevent unplanned ...

In the trial, treatment with Enhertu and Perjeta delayed cancer growth for longer than the established regimen of Perjeta, Herceptin and chemotherapy, which is known by the acronym THP.

Rapidly growing antimicrobial resistance (AMR) against antibiotics has propelled the development of synthetic antimicrobial peptides (AMPs) as potential antimicrobial agents. An antimicrobial peptide ...

Results: SAR-trastuzumab was labelled with either 64 Cu or 67 Cu at room temperature with high (>99%) radiochemical yields and purity. PET/CT imaging 48 hours after administration with 64 ...

On the basis of phase 2 studies, trastuzumab deruxtecan was approved for patients with human epidermal growth factor receptor 2 (HER2)–positive metastatic gastric cancer or gastroesophageal ...

A global review of extreme heat over the past 12 months (May 2024 to May 2025), climate change’s influence on that heat, and strategies to prevent increasingly frequent and intense heat from ...