Tremendous resources have been spent in efforts to elucidate the mechanisms of action, safety, optimal combination therapies and mechanisms of resistance, as well as the methodological validations ...

In breast cancer, HER2-targeted therapy with trastuzumab has gained significant attention, owing to the dramatic response observed in a subset of HER2-positive patients. The mechanisms of action ...

In this GEN webinar, Dave Lahr, PhD, Senior Director of Bioinformatics at Foghorn Therapeutics, discusses chromatin regulation and epigenetic mechanisms that shape transcriptional responses to ...

The question of putative mechanisms of action continues to haunt psychopharmacology.

Baselga and colleagues [14] treated 46 women with HER2-overexpressing MBC with an initial dose of trastuzumab 250 mg i.v., followed by 10 weekly maintenance doses of 100 mg. Patients with a ...

CRISPR construct to genetically ablate the GABA transporter GAT3 in the mouse visual cortex, with effects on population-level neuronal activity. This work is important, as it sheds light on how GAT3 ...

This meta-analysis from two nationwide cohorts indicates that SSRI and SNRI augmentation therapies for people with ...