Negative regulation by anti-inflammatory ... often because they couple directly to various transcriptional machineries. For example, transcription factor IID (TFIID), which is essential for ...

Tumor cells in colorectal cancer exploit an important signaling pathway that normally controls embryo development.

This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present ...

Read how the North African Dementia Registry will use multiomics data to reveal new insights on Alzheimer’s genetic risk.

Non-coding RNAs (ncRNAs) are RNA molecules that do not encode proteins but are involved in dynamic cellular regulatory ...

Several genetic studies have attempted to explore the fungal factors involved in antiviral responses, but the exact genes and ...

The molecular pathways involved in antiviral defenses and counter-defenses in host-pathogen systems remain unclear. Researchers have used Neurospora crassa as a model organism to explore how RNA ...

This valuable study focuses on defining how the HSP70 chaperone system utilizes J-domain proteins to regulate the heat shock response-associated transcription factor HSF1. Using a combination of ...

The expression of symptoms of viral infections is a byproduct of complex virus-host molecular pathways. These remain largely ...

This study develops tools to measure LRRK2 activity and expression in immune cells relevant to Crohn’s disease, revealing ...

"Supply and demand" constraints limit the body's ability to produce the various proteins needed for critical life functions, ...