Background: Mycophenolate mofetil (MMF) inhibits IMPDH and disrupts de novo purine synthesis which is preferred by glioblastoma (GBM) whilst normal brain prefers resource efficient salvage pathway. A ...

Background: Mycophenolate mofetil (MMF) inhibits IMPDH and disrupts de novo purine synthesis which is preferred by glioblastoma (GBM) whilst normal brain prefers resource efficient salvage pathway. A ...

Tour de France 2025 introduces an entirely new refuelling mechanism, revolutionizing race strategies. From now on, at the start of your races, you'll only have access to one type of feed.

News Release 24-Mar-2025 Researchers achieve de novo biosynthesis of plant lignans using synthetic yeast consortia Peer-Reviewed Publication Dalian Institute of Chemical Physics, Chinese Academy ...

Uncoupling protein 1 (UCP1, SLC25A7) is responsible for the thermogenic properties of brown adipose tissue. Upon fatty acid activation, UCP1 facilitates proton leakage, dissipating the mitochondrial ...

For de Veer, the emphasis on the wolf sounds is also representative of Romy's personal transformation. "There's almost a werewolf situation going on in this movie," de Veer said.

We performed real-time polymerase-chain-reaction (RT-PCR) analysis followed by Sanger sequencing to detect XCV in serum samples obtained from 792 participants recruited during May through July of ...

The FDA issued its first stamp of approval for a cell or gene therapy back in 2017 to Novartis' Kymriah. Now, seven years and many approvals later, innovation in the space has hit new heights with ...

Preclinical data show intracellular uptake of a ligand-siRNA conjugate in vitro using megalin, an endogenous, endocytic recycling receptor on proximal tubular cells of the kidney Megalin-mediated ...

New research now demonstrates an alternative approach, a synthesis-free method that uses a universal DNA template to encode data. (Nature 2024, DOI: 10.1038/s41586-024-08040-5) ...

Remodeling of the secretory pathway is coordinated with de novo membrane formation in budding yeast gametogenesis. iScience, 2024; 27 (10): 110855 DOI: 10.1016/j.isci.2024.110855 ...

News Release 27-Sep-2024 Elucidating the mechanism underlying de novo membrane formation during gametogenesis Peer-Reviewed Publication University of Tsukuba ...