MTX disrupts these processes by impeding DHFR, causing intracellular depletion of THF, particularly in rapidly dividing cells. Beyond DHFR inhibition, MTX and the polyglutamate forms impede de novo ...

Background: Mycophenolate mofetil (MMF) inhibits IMPDH and disrupts de novo purine synthesis which is preferred by glioblastoma (GBM) whilst normal brain prefers resource efficient salvage pathway. A ...

Since our founding in 1973, The Heritage Foundation has been working to advance the principles of free enterprise, limited government, individual freedom, traditional American values, and a strong ...

IEEE Code of Ethics on professional activities. We, the members of the IEEE, in recognition of the importance of our technologies in affecting the quality of life throughout the world, and in ...

By Pooja Toshniwal Paharia. A recent study in Nature Communications examined how RNA polymerase I (Pol I) responds to abasic (Ap) site formation—the most common type of DNA damage. The ...

UNESCO World Heritage Centre. Located in the arid Peruvian coastal plain, some 400 km south of Lima, the geoglyphs of Nasca and the pampas of Jumana cover about 450 km 2.These lines, which were ...

Poly(ethylene terephthalate) (PET) is the most abundant polyester plastic, with almost 70 million tons manufd. annually worldwide for use in textiles and packaging3. The main recycling process for PET ...

Structural dynamics of water and its hydrogen-bonding networks play an important role in enzyme function via the transport of protons, ions, and substrates. To gain insights into these mechanisms in ...

FIGURE 2. The function of artificial cells could be ... several models of membrane division induced by physical mechanism, chemical synthesis, or fundamental biological processes had ... De Novo ...

Authors, contributors, and how to cite this module. Module 12 has been written and compiled by: Andrew Booth, Professor in Evidence Synthesis in the Sheffield Centre for Health and Related Research ...