Programmed cell death serves as a critical defense mechanism during viral infection. The kinases RIPK1 and RIPK3, central ...

The FDA approved taletrectinib for ROS1-positive NSCLC. The agent shows efficacy for both new and pretreated cases, including ...

More than 40 million people worldwide are living with HIV-1, which continues to be a major global health challenge due to its ...

Acetylation of the TLR4 signalosome TIR domains significantly enhances signaling activation via NF-κB rather than IRF3 pathways. Induction of NF-κB signaling is responsible for gene expression changes ...

aDepartment of Neurosurgery, The First Hospital of China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang City 110001, China bCollege of Life and Health Sciences, ...

SY has anti-inflammatory effect, as it can inhibit IκBα phosphorylation to impede the NF-κB signaling pathway and p53 nuclear translocation. Besides, SY can limit the release of pro-inflammatory ...

Two signaling pathways, the high mobility group box-1 (HMGB1)/toll-like receptor 4 (TLR4) and interleukin-1β (IL-1β)/interleukin-1 receptor 1 (IL-1R1) pathways, have become the focus of research in ...

"We found suppressing TLR4 signaling a day after concussive brain injury, common to sports and traffic accidents, reduces excitability and improves working memory performance a week to a month ...

Whether anti-viral immune signaling pathways are also suppressed in these patients is unclear. We evaluated suppression of the TLR4 and the anti-viral retinoic acid-inducible gene-I (RIG-I) pathways ...

In this paper the function of TLR5 as part of the TLR4 signaling pathway for LPS and for hyaluronan recognition is described. Using TLR5 KO mice and human subjects carrying a TLR5 mutation LPS ...