However, Blander and Medzhitov also revisit our paper in which we reported no influence of TLR signaling on phagosome ... on the idea that some phagocytic receptors are 'more equal than others'.

Toll-like receptor. Toll-like receptors (TLRs) are one of the largest and best-studied families of pattern-recognition receptors of the innate immune system. TLRs recognize pathogen- and danger ...

The American Association for Cancer Research (AACR) today announced its newly elected 2025 class of Fellows of the AACR Academy.

STING/TLR-agonist Antibody-Drug Conjugates and mRNA technologies You will also have the opportunity to ask any burning questions and go back to your teams with a full picture of the innate ...

Eikon’s lead candidate EIK1001 is being investigated for melanoma in combination with MSD’s Keytruda in a Phase III trial.

Company Achieves Key Clinical Milestone with more than 20 Patients Enrolled in Weekly Dosing Cohort of Phase 1 Trial of Decoy20Pharmacodynamic ...

They identified three types of cell surface receptors through which buprenorphine appeared to be triggering inflammation and membrane-weakening: the μ-opioid receptor, Toll-like Receptor 4 (TLR4 ...

A new review highlights how gut microbiome imbalances contribute to cardiovascular disease by altering short-chain fatty ...

The lead Eikon drug, EIK1001, is a small molecule designed to hit toll-like receptors 7 and 8 (TLR7/8). Activating these receptors is intended to spark an immune response that fights cancer.

One of these programs, a toll-like receptor 7 and 8 agonist immune modulator acquired from Seven and Eight Biopharma, now leads Eikon’s clinical pipeline. The asset, renamed EIK1001, is ...

Cardiovascular disease (CVD) is the leading cause of death and disease burden worldwide. Macrophages are important components of the internal immune cells, which profoundly affects the internal ...