Prominent clusters include synaptic vesicle proteins, as well as proteins involved in energy metabolism and ion homeostasis. Using subcellular fractionation and electron microscopy we provide further ...

These results suggest that Aβ and αS cooperate to accelerate the production of toxic oligomers, whose main toxicity is the inhibition of vesicle fusion and consequently the disruption of synaptic ...

The impulse of an action potential causes the release of acetylcholine from synaptic vesicles (each containing about 10,000 molecules of acetylcholine) diffusing across the 20-nm gap to the ...