Similarly to the MYC super-enhancers, common enhancer elements present in the 8q24 cancer-risk locus upstream of MYC have tissue-specific activity and cell type-specific interactions with the MYC ...

The researchers went on to demonstrate that deleting the super-enhancer or knocking out the hnRNPF gene in cell lines effectively slowed the growth of pancreatic cancer cells by more than 80%.

The researchers then took a closer look at the 15 most frequent super-enhancers. They were able to demonstrate that these enhancer elements regulate molecules that are involved in key cellular ...

"Ultimately, super-enhancers may well become important targets for therapeutic intervention." This work was supported by grants from the National Institutes of Health (grants HG002668, CA109901 ...

Super-enhancers improve dialog between genes, disease Date: October 10, 2013 Source: Whitehead Institute for Biomedical Research Summary: Having recently discovered a set of powerful gene ...

Molecular super enhancers: A new key for targeted therapy of brain cancer in children Peer-Reviewed Publication. German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) ...

Scientists at the Whitehead Institute report the discovery of a set of gene regulators dubbed “super-enhancers” that control cell state and identity. genprowebdirectory ...

Having recently discovered a set of powerful gene regulators that control cell identity in a few mouse and human cell types, Whitehead Institute scientists are now showing that these regulators ...

Molecular super enhancers: A new key for targeted therapy of brain cancer in children. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2017 / 12 / 171220131715.htm ...

Having recently discovered a set of powerful gene regulators that control cell identity in a few mouse and human cell types, Whitehead Institute scientists are now showing that these regulators—which ...