All enhancer elements acted in an additive manner, and no single element was critical for globin expression or chromatin structure.

The discovery of cancer mutations that affect enhancer elements has generated interest in mapping and targeting cancer-specific enhancers, as discussed in this Review.

Findings point to potential therapeutic targets, and indicate that the super-enhancer could represent a marker to monitor pancreatic cancer progression.

The researchers then took a closer look at the 15 most frequent super-enhancers. They were able to demonstrate that these enhancer elements regulate molecules that are involved in key cellular ...

In April, Young reported that while the total number of genetic control elements is likely in the millions, only a few hundred super-enhancers regulate the key genes that give each cell its unique ...

Scientists at the Whitehead Institute report the discovery of a set of gene regulators dubbed “super-enhancers” that control cell state and identity.

In April, Young reported that while the total number of genetic control elements is likely in the millions, only a few hundred super-enhancers regulate the key genes that give each cell its unique ...

In April, Young reported that while the total number of genetic control elements is likely in the millions, only a few hundred super-enhancers regulate the key genes that give each cell its unique ...

Groups of enhancers with strong enhancer potential for key cellular processes are also called super enhancers. These have already been linked to tumor development in other cancer types.

Groups of enhancers with strong enhancer potential for key cellular processes are also called super enhancers. These have already been linked to tumor development in other cancer types.

In April, Young reported that while the total number of genetic control elements is likely in the millions, only a few hundred super-enhancers regulate the key genes that give each cell its unique ...