The discovery and development of this first sulfonamide drug was a key breakthrough in the chemotherapy of infectious diseases, for which Domagk received the Nobel Prize in 1939.

1-Octanol/water partition coefficients log Kow of 38 sulfonamides were determined by the isothermal saturation method. These values were used both for direct correlation and as test data for the ...

Electron-withdrawing sulfonamide groups attached to the bidentate segment of the multidentate ligand L3 display dual σ/π effects which have been rationalized at the ab initio level. The resulting ...