By putting a carbon atom in place of a core oxygen, chemists constructed an opioid that blocks pain with less respiratory ...

MDM2, a key negative regulator of the tumor suppressor p53, has emerged as a compelling therapeutic target in human cancer. This Viewpoint summarizes the discovery of a potent and orally bioavailable ...

The Journal of Medicinal Chemistry is pleased to present its latest Drug Discovery Collection, this time dedicated to contributions from Czechia. Czechia (and former Czechoslovakia) has a long ...