Figure 2: Crystal structure of a BRAF monomer yields insights in the allosteric control by dimerization by the AS. Figure 3: Dimerization and activity of oncogenic BRAF mutants V600E and V600K and ...

Newest member of the rapidly growing sulfanilamide family is a little number called N¹ dodecanoylsulfanilamide. It is a combination of the parent drug with part of a fat. Last week at the ...

Since the discovery of Prontosil in 1932, sulfonamide antibiotics have been ... Consequently, it is difficult to modify drug structure or customize therapeutic regimes in order to better serve ...

To test this hypothesis these workers administered sulfanilamide, a specific inhibitor of carbonic anhydrase, 2 to dogs, presumably inhibiting the formation of carbonic acid in the renal parenchyma.

Only since February 1935 has the drug sulfanilamide been known. In the past three years it has proven so useful as a treatment for “coccus” infections (streptococcus, gonococcus, meningococcus ...